منابع مشابه
Resetting the suprachiasmatic nucleus clock.
Recent research on the cellular basis of circadian rhythmicity has stressed the importance of clock genes for the maintenance of normal rhythmicity. There have been tremendous advances in our understanding of the inter-relationships of the various genes known to generate the rhythms. We know relatively little, however, about the way animals maintain their rhythmicity under normal seasonally cha...
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Like the biological clock in the body, replication of each cell type (even different cells of the same organism) follows a timing program. Abnormal function of this timer could be an alarm for a disease like cancer. DNA replication starts from a specific point on the chromosome that is called the origin of replication. In contrast to prokaryotes in which DNA replication starts from a single ...
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The signaling pathways by which light and activity shift the circadian clock are not well understood. In this issue of Neuron, Cheng et al. analyze mice lacking Dexras1 (a Ras family GTPase protein) and demonstrate an important role for G(i/o) signaling mediating both photic and nonphotic phase shifts of the circadian clock.
متن کاملRapid resetting of the mammalian circadian clock.
The suprachiasmatic nuclei (SCN) contain the principal circadian clock governing overt daily rhythms of physiology and behavior. The endogenous circadian cycle is entrained to the light/dark via direct glutamatergic retinal afferents to the SCN. To understand the molecular basis of entrainment, it is first necessary to define how rapidly the clock is reset by a light pulse. We used a two-pulse ...
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MYC deregulation is common in human cancer and has a role in sustaining the aggressive cancer stem cell populations. MYC mediates a broad transcriptional response controlling normal biological programmes, but its activity is not clearly understood. We address MYC function in cancer stem cells through the inducible expression of Omomyc-a MYC-derived polypeptide interfering with MYC activity-taki...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2012
ISSN: 0148-396X
DOI: 10.1227/01.neu.0000414944.63848.c2